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SUMMARY:BioCity Turku Guest Seminar: Nobel laureate Shimon Sakaguchi
DTSTART:20260512T093000Z
DTEND:20260512T103000Z
DTSTAMP:20260517T093800Z
UID:indico-event-233@eve.utu.fi
CONTACT:biocityturku@bioscience.fi
DESCRIPTION:\nBioCity Turku Guest Seminar\n12th May at 12:30Hybrid eventin
  Presidentti auditorium\, BioCity and ZoomFlyer\nCoffee and sandwiches ser
 ved at 12:15\n \nNobel laureate\, Prof. Shimon Sakaguchi\, University of 
 Osaka\, JapanTreg control of immune responses\, especially autoimmunity an
 d tumor immunity\nHost: Riitta Lahesmaa (rilahes@utu.fi)\nLink to join the
  event online: https://utu.zoom.us/j/69149423371\n \nSakaguchi is current
 ly a Distinguished Honorary Professor at the Immunology Frontier Research 
 Center (IFReC) Osaka University\, Japan. He obtained an M.D. in 1976 and a
  Ph.D. in 1982 from Kyoto University\, Japan\, where he was trained as a p
 athologist and immunologist. After performing postdoctoral studies at John
 s Hopkins University and Stanford University as a Lucille P. Markey Schola
 r\, he served as an Assistant Professor in the Department of Immunology at
  the Scripps Research Institute. He returned to Japan in 1991 and continue
 d his immunology research as the Head of the Department of Immunopathology
  at Tokyo Metropolitan Institute of Gerontology\, Tokyo. From 1998 to 2011
 \, he was a Professor of Institute for Frontier Medical Sciences Kyoto Uni
 versity and served as the Director of the Institute from 2007 to 2011. In 
 2011\, his lab moved to Osaka University. He was elected to Foreign Member
  of National Academy of Sciences USA in 2012\, and has been awarded many i
 nternational prizes including Cancer Research Institute’s William B. Col
 ey Award in 2004\, Keio Medical Science Prize in 2008\, Canada Gairdner In
 ternational Award in 2015\, the Crafoord Prize in 2017\, the German Immuno
 logy Award in 2019\, the Paul Ehrlich and Ludwig Darmstaedter Prize in 202
 0\, the Robert Koch Prize in 2020\, and Debrecen Award for Molecular Medic
 ine in 2023\, and the Nobel Prize for Physiology or Medicine in 2025. He r
 eceived an honorary degree from the University of Birmingham\, UK\, in 201
 9\, the Medal with Purple Ribbon from the Government of Japan in 2009\, an
 d the Order of Culture\, the highest accolade for Japanese scholars of hum
 anities and natural sciences\, from the Emperor of Japan in 2019.\n \nSel
 ected publications\nTanaka A\, Sakaguchi S. T Cell Receptor Signaling and 
 Immune Tolerance: From Autoimmunity to Cancer Immunity. Annu Rev Immunol. 
 2026 Mar 2. doi: 10.1146/annurev-immunol-082724-025403.\nOsaki M\, Sakaguc
 hi S. Soluble CTLA-4 regulates immune homeostasis and promotes resolution 
 of inflammation by suppressing type 1 but allowing type 2 immunity. Immuni
 ty. 2025 Mar 26:S1074-7613(25)00123-2. doi: 10.1016/j.immuni.2025.03.004.\
 nIchiyama K\, Long J\, Kobayashi Y\, Horita Y\, Kinoshita T\, Nakamura Y\,
  Kominami C\, Georgopoulos K\, Sakaguchi S. Transcription factor Ikzf1 ass
 ociates with Foxp3 to repress gene expression in Treg cells and limit auto
 immunity and anti-tumor immunity. Immunity. 2024 Jul 30:S1074-7613(24)0035
 9-5. doi: 10.1016/j.immuni.2024.07.010. \nTay C\, Tanaka A\, Sakaguchi S. 
 Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy. 
 Cancer Cell. 2023 Mar 13\;41(3):450-465. doi: 10.1016/j.ccell.2023.02.014.
 \nKidani Y\, Nogami W\, Yasumizu Y\, Kawashima A\, Tanaka A\, Sonoda Y\, T
 ona Y\, Nashiki K\, Matsumoto R\, Hagiwara M\, …\, Mori M\, Doki Y\, Ohk
 ura N\, Sakaguchi S. CCR8-targeted specific depletion of clonally expanded
  Treg cells in tumor tissues evokes potent tumor immunity with long-lastin
 g memory. Proc Natl Acad Sci U S A. 2022 Feb 15\;119(7):e2114282119. doi: 
 10.1073/pnas.2114282119.\n\nhttps://eve.utu.fi/event/233/
LOCATION:Presidentti auditorium (BioCity)
URL:https://eve.utu.fi/event/233/
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